4.6 Lesson 6: Macromolecules, Synthesis, and Hydrolysis

  • Macromolecules are composed of long complex chains of molecules (polymers) made up of simpler, smaller subunits (monomers). There are four classes of macromolecules that constitute all living matter: carbohydrates, lipids, proteins, and nucleic acids. While they have different structures and functions, they are all joined together in a process known as dehydration synthesis, in which a covalent bond is formed between two monomers by releasing a water molecule.  Also, they can all be broken down by a process called hydrolysis where a water molecule is used up.
  • The carbohydrate polymer is made from monomers called monosaccharides.
  • The lipid polymer is made from monomers called glycerol and fatty acids.
  • The protein polymer is made from monomers called amino acids.
  • The nucleic acid polymer is made from monomers called nucleotides.
  • Dehydration synthesis and hydrolysis are processes that build up or break down macromolecules. 
  • Dehydration means to take water out and synthesis means to build up. Therefore dehydration synthesis means the building up of polymers from monomers, while taking water out. 
    • ex. in carbohydrates, an H ion from one monosaccharide and an OH ion from another are taken out, they form water. The two monosaccharides are then joined together by a bond called a glycosidic bond.
  • Hydrolysis is the reverse of dehydration synthesis. It is a chemical process in which a molecule is cleaved into two parts by the addition of water. One fragment of the parent molecule gains a hydrogen ion (H+) from the additional water molecule. The other group collects the remaining hydroxyl group (OH ).
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